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Table 6 Adjusted differences between groups at 24 months

From: Effects of the Norfolk diabetes prevention lifestyle intervention (NDPS) on glycaemic control in screen-detected type 2 diabetes: a randomised controlled trial

Analysis INT-DPM vs INT p INT vs CONTROL p INT-DPM vs CONTROL p Combined intervention vs CONTROL p
HbA1c (mmol/mol) 0.11 (−2.46, 2.67) 0.93 −1.29 (−3.77, 1.19) 0.31 −1.18 (−3.8, 1.5) 0.38 −1.24 (−3.35, 0.87) 0.25
Fasting plasma glucose (mmol/l) −0.09 (−0.5, 0.32) 0.66 0.01 (−0.38, 0.41) 0.95 −0.06 (−0.5, 0.4) 0.78 −0.03 (−0.36, 0.31) 0.87
Weight (kg) −0.46 (−2.43, 1.51) 0.39 −1.51 (−4.97, 1.94) 0.39 −1.93 (−5.6, 1.7) 0.30 −1.7 (−4.34, 0.94) 0.2
Body mass index (kg/m2) −0.17 (−0.87, 0.54) 0.46 −0.47 (−1.72, 0.79) 0.46 −0.63 (−1.96, 0.7) 0.35 −0.54 (−1.5, 0.41) 0.26
Body fat (%)a −0.29 (−1.65, 1.07) 0.67 1.46 (−0.02, 2.94) 0.05 1.14 (−0.32, 2.59) 0.13 1.3 (0.1, 2.49) 0.03
Body fat mass (kg)a −0.62 (−2.36, 1.12) 0.48 0.98 (−0.95, 2.92) 0.32 0.37 (−1.58, 2.33) 0.71 0.69 (−0.87, 2.26) 0.38
Visceral fat scorea 0.16 (−0.5, 0.82) 0.63 −0.27 (−0.99, 0.45) 0.45 −0.36 (−1.15, 0.43) 0.37 −0.06 (−0.66, 054) 0.84
Waist (cm) 0.41 (−2.76, 1.93) 0.73 −0.05 (−1.91, 1.81) 0.87 −0.28 (−2.6, 2.1) 0.81 −0.05 (−1.91, 1.81) 0.96
Physical activity: MET min/weekb −698 (−2079, 683) 0.32 482 (−718, 1681) 0.43 −223 (−1433, 987) 0.71 198 (−823, 1220) 0.70
Physical activity: resistance days/wkb 1.03 (0.32, 3.31) 0.96 2.06 (0.71, 5.99) 0.18 1.71 (0.59, 4.94) 0.32 1.90 (0.79, 4.59) 0.15
Physical activity: min sitting/wkb −115 (−220, −11) 0.03 18.5 (−91.9, 129) 0.74 −94.6 (−200, 11) 0.08 −27.7 (−115, 60) 0.53
Fat scale scorec 0.04 (−0.11, 0.18) 0.6 0.11 (−0.02, 0.23) 0.09 0.15 (0.02, 0.27) 0.02 0.12 (0.02, 0.23) 0.02
Fibre scale scorec 0.02 (−0.1, 0.15) 0.7 0.07 (−0.08, 0.21) 0.36 0.09 (−0.07, 0.25) 0.26 0.08 (−0.04, 0.19) 0.19
General well-being score WBQ-12d −0.91 (−2.91, 1.09) 0.37 1.09 (−0.69, 2.88) 0.23 0.48 (−1.41, 2.37) 0.62 0.76 (−0.76, 2.27) 0.33
EQ-5Dd −0.08 (−0.5, 0.33) 0.69 −0.07 (−0.43, 0.29) 0.7 −0.14 (−0.5, 0.22) 0.44 −0.1 (−0.4, 0.19) 0.5
ADDqold 0 (−0.07, 0.08) 0.97 −0.01 (−0.07, 0.05) 0.72 0 (−0.07, 0.07) 0.99 0 (−0.06, 0.05) 0.89
HOMA–B (%)e −3.05 (−14.5, 8.5) 0.6 2.8 (−7.04, 12.6) 0.57 1.41 (−7.47, 10.29) 0.75 2.32 (−6.02, 10.66) 0.58
HOMA–S (%)e −5.3 (−19.6, 8.9) 0.46 0.95 (−15.6, 13.7) 0.90 −5.88 (−20.9, 9.2) 0.44 −3.12 (−15.3, 9.05) 0.61
  1. Data adjusted for baseline value for each variable and shown as change in mean and 95% CI. aFat mass (kg and %) by Tanita body composition analyser. bPhysical activity scales derived from international physical activity questionnaire IPAQ. cDietary fat and fibre scores based on self-reported Diet Behaviour Questionnaire (DBQ)—higher fat scale scores indicate lower fat intake. d Well-being score (WBQ-12) questionnaire, health-related quality of life score (EQ-5D) questionnaire, and ADDQoL. eHomeostasis model assessment (HOMA) of baseline insulin sensitivity (S) and beta cell function (B)