Table 1 Number of cancer cases and controls and statistical power in Mendelian randomization study on association of circulating vitamin C concentration with risk of site-specific cancers
From: Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
| Cancer type | Study/Consortium | Cases | Controls | Minimum detectable OR (R2=0.0187) |
|---|---|---|---|---|
| Lung (bronchus) cancer | UK Biobank | 2,120 | 454,228 | 0.55/1.45 |
| Prostate cancer | 5,796 | 203,012 | 0.75/1.25 | |
| Breast cancer | 10,892 | 236,648 | 0.80/1.21 | |
| Colon cancer | 3,221 | 453,127 | 0.64/1.36 | |
| Rectal cancer | 2,202 | 454,146 | 0.56/1.44 | |
| Lung cancer | ILCCO | |||
| Overall | 11,348 | 15,861 | 0.77/1.28 | |
| Adenocarcinoma | 3,442 | 14,894 | 0.64/1.42 | |
| Squamous cell carcinoma | 3,275 | 15,038 | 0.63/1.42 | |
| Prostate cancer | PRACTICAL | |||
| Overall | 79,148 | 61,106 | 0.89/1.12 | |
| Breast cancer | BCAC | |||
| Overall | 133,384 | 113,789 | 0.92/1.09 | |
| ER-positive | 69,501 | 105,974 | 0.90/1.11 | |
| ER-negative | 21,468 | 105,974 | 0.85/1.16 |